Modeling of blood microcirculation, heat and mass transfer in human tissues
DOI:
https://doi.org/10.17721/1812-5409.2018/4.8Abstract
A mathematical model of the structure of the blood vessels system which provides blood microcirculation in the superficial tissues of human, namely the skin, to provide blood supply as a fluid, which heats / cools, and determines thermoregulation in changes of ambient temperature and overheating / supercooling is proposed. The model is based on data from current studies of the structure of microcirculatory beds based on microCT technologies. The microvascular system is modeled as a fractal binary tree optimized for uniform supply of a nutrient fluid (blood for biological tissues) due to the homogeneous distribution of capillaries, optimal values for diameters, lengths and branching angles in bifurcations of tubes that provide flow distribution with minimal energy costs. The model has been developed to use in computer-based monitoring systems for the planning of physiotherapy procedures for different diseases.
Key words: optimal fluid transport systems, microcirculation, mathematical modeling.
Pages of the article in the issue: 58-61
Language of the article: Ukrainian
References
BLITTERSWIJK, C.V., BOER, J.B. (2014) Tissue Engineering. Academic Press. 896p.
KIZILOVA, N., KOROBOV, A. (2018) On biomedical engineering techniques for efficient phototherapy. Int. J. Biosen. Bioelectron. 4. 289–295.
KIZILOVA, N., KOROBOV, A. (2016) Mechanisms of influence of low-level optical radiation on the microcirculatory system. A review. Photobiol. Photomed. 1. 79-93.
KIZILOVA, N., KOROBOV, А. (2017) Modeling of blood microcirculation and heat and mass transfer in human tissues. (2017) Bulletin Kiev National University, Series “Physical and Mathematical Sciences”. 4. 37-42. [in Ukrainian]
DAI, W., BEJAN, A., TANG, X., LE ZHANG,, NASSAR, R. (2006) Optimal temperature distribution in a three dimensional triple-layered skin structure with embedded vasculature. J. Appl. Phys. 99. 104702.
HUANG, ZH., HWANG, Y., AUTE, V. RADERMACHER, R. (2016) Review of Fractal Heat Exchangers. Intern. Refrigeration and Air Conditioning Conf. Purdue Univ. 1725.
ZENG, X., DAI, W., BEJAN, A. (2010) Vascular Countercurrent Network for 3-D Triple-Layered Skin Structure with Radiation Heating. Numer. Heat Transfer, Part A. 57. 369-391.
ORNDORFF, C., PONOMAREV, S., DAI, W., BEJAN, A. (2017) Thermal analysis in a triplelayered skin structure with embedded vasculature, tumor, and gold nanoshells. Intern. J. Heat Mass Transfer. 111. 677–695.
LA BARBERA, M. (1990) Principles of design of fluid transport systems in zoology. // Science. 249. 992–1000.
KIZILOVA, N. (2004) Computational approach to optimal transport network construction in biomechanics. Lecture Notes in Computer Sci. 3044. 476–485.
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).